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Related Experiment Videos

Small drug sample fabrication of controlled release polymers using the microextrusion method

K L Haik-Creguer1, G L Dunbar, B A Sabel

  • 1Central Michigan University, Department of Psychology, Mount Pleasant, USA.

Journal of Neuroscience Methods
|May 30, 1998
PubMed
Summary

Microextrusion offers a reproducible method for creating ethylene vinylacetate polymer (EVA) implants for controlled drug delivery. This technique enables precise incorporation of valuable pharmaceuticals for sustained release over extended periods.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Drug Delivery Systems

Background:

  • Ethylene vinylacetate polymer (EVA) is established for controlled-release implant fabrication.
  • Existing methods like solvent evaporation have limitations in controllability and reproducibility.
  • Challenges exist in incorporating small amounts of expensive drugs into polymer matrices.

Purpose of the Study:

  • To introduce and validate microextrusion as a superior fabrication method for EVA-based controlled-release devices.
  • To demonstrate the method's capability for incorporating small quantities of high-value drugs.
  • To assess the controlled release kinetics of various neuroactive compounds from microextruded EVA implants.

Main Methods:

  • Development of a microextrusion technique for fabricating EVA implants.

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  • Incorporation of neurotoxic and neurotherapeutic compounds (e.g., alpha-methyl-p-tyrosine, diazepam, quinolinic acid, phencyclidine) into EVA.
  • Spectrophotometric analysis to quantify drug release rates over time.
  • Evaluation of polymer fabrication with minimal solvent usage.

    • Main Results:

    • Microextrusion allows for highly reproducible fabrication of EVA implants, even with small drug quantities.
    • Controlled, zero-order release kinetics were achieved for multiple neuroactive compounds.
    • Sustained drug release was observed for up to 120 days.
    • Daily release rates varied, with diazepam at 97.6 microg/day and phencyclidine at 18.4 microg/day.

    Conclusions:

    • Microextrusion is a valuable and reproducible method for fabricating controlled-release polymer devices.
    • The technique facilitates the incorporation of scarce and expensive drugs into EVA matrices.
    • This method offers an advantage by significantly reducing solvent use in polymer fabrication.