[Morphologic manifestations of brain edema during experimental stimulation of the hypothalamus]

By methods of neurohistology, electron microscopy and histochemistry magistral and pial arteries of brain, cerebral and cerebellar cortex as well as main nuclear structures of midbrain, afterbrain and oblongated marrow were studied in 39 experimental and 33 control rabbits in dosed effect of electric current exerted on hypothalamus through electrodes introduced stereotaxically into posterior hypothalamic field. Dynamics of intensity of luminescence and distribution density of adrenergic nerve structures in the arteries studied, swelling and vacuolization of endotheliocytes in cerebral arterioles and capillaries, destruction of mitochondria and lipid drops accumulation in them were demonstrated, plasmorrhages and diapedese hemorrhages were noted. Edematous changes combined with alterations of oxidation and protein metabolism enzymes activity were detected in neurons and gliocytes. A conclusion is made on adequacy of the model of experimental hypothalamus stimulation employed in the study in order to obtain centrogenic edema for meeting modern goals of neurosurgical clinic.