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[Fungi in the intestine--normal flora or pathogens?]
1Klinik für Innere Medizin A, Ernst-Moritz-Arndt-Universität Greifswald.
Abstract:
Candida spp. und C. albicans are common within the microbial ecosystem of the human orointestinal tract. Candida in low quantities is found at various sites in healthy subjects. In patients with typical risk factors, mainly in immunocompromised hosts, an increased growth of Candida occurs. In cases with multiple sites colonised there will be an increased risk of severe Candida infections. The metabolic activity of Candida in the gut is very low under anaerobic condition and limitation of nutrients.
Insights
Candida species, including Candida albicans, are common in the human gut. Overgrowth of Candida, particularly in immunocompromised individuals, increases the risk of severe infections.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- Candida species, including Candida albicans, are prevalent in the human orointestinal tract's microbial ecosystem.
- Low quantities of Candida are typically found in healthy individuals across various body sites.
Purpose of the Study:
- To investigate the implications of Candida overgrowth in the human orointestinal tract.
- To understand the risk factors associated with severe Candida infections.
Main Methods:
- Review of existing literature on Candida colonization and infection.
- Analysis of risk factors contributing to Candida overgrowth, focusing on immunocompromised hosts.
Main Results:
- Increased Candida growth is observed in patients with risk factors, especially immunocompromised individuals.
- Colonization at multiple sites elevates the risk of severe Candida infections.
- Candida exhibits low metabolic activity in the gut under anaerobic conditions and nutrient limitation.
Conclusions:
- Candida overgrowth, particularly in immunocompromised hosts, poses a significant risk for severe infections.
- Understanding colonization patterns and host factors is crucial for managing Candida-related diseases.