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[Candida infections in infancy and early childhood]

R Schwarze1, C Seebacher, R Blaschke-Hellmessen

  • 1Kinderklinik der Technischen Universität Dresden.

Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung
|June 2, 1998
PubMed

Insights

Candida infections in infants are often caused by Candida albicans. Treatment varies from topical polyenes for skin/mucosal infections to combination therapies or fluconazole for systemic cases, with hygiene and surveillance as key preventatives.

Area of Science:

  • Medical Mycology
  • Pediatric Infectious Diseases

Context:

  • Infant Candida infections present as skin, mucosal, or systemic candidiasis.
  • Candida albicans is the predominant causative agent in 80-90% of infant cases.
  • Neonatal infections often occur perinatally, while older children may have underlying predisposing conditions.

Purpose:

  • To review the epidemiology, diagnosis, and treatment of Candida infections in infants.
  • To outline effective therapeutic strategies for various forms of candidiasis in this age group.
  • To discuss prophylactic measures for preventing Candida infections in at-risk infants.

Summary:

  • Diagnosis relies on microscopy, culture, and serological markers (antigen/antibody titers).
  • Topical polyenes (nystatin, amphotericin B) are effective for superficial infections.
  • Systemic candidiasis treatment involves amphotericin B with 5-flucytosine or fluconazole as an alternative, considering potential side effects.

Impact:

  • Provides a comprehensive overview of infant candidiasis management.
  • Highlights effective antifungal treatments and diagnostic approaches.
  • Emphasizes the importance of hygiene, surveillance, and prophylactic antimycotics for prevention.

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