[Effectiveness of fluoxetine (portal) in atypical depressions]

Efficiency of fluoxetine (one of the selective serotonin reuptake inhibitors) was examined in the course of treatment of 24 patients with atypical depressions that were characterized by prevalence of either negative (12 patients) or positive (12 patients) affectivity. Fluoxetine was more effective in patients with domination of negative affectivity (apathias, angedonias, alexithymias). Total efficiency of fluoxetine was equal to 91% in group with prevalence of negative affectivity and 41% with prevalence of positive affectivity. In the latter group the side-effects were more pronounced that resulted in prescription of corrective therapy.