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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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MRI Study of the Brain Structural Characteristic in Persecutory Delusions.

A S Tomyshev1, A N Dudina2, E V Ilina3

  • 1Mental Health Research Center, Moscow, Russia. alexander.tomyshev@gmail.com.

Bulletin of Experimental Biology and Medicine
|February 13, 2025
PubMed
Summary

Structural MRI revealed reduced gray matter thickness in the cortex and smaller volumes in the left thalamus and hippocampus for patients with schizophrenia and delusional disorder. Brainstem structures showed no significant alterations.

Keywords:
MRIdelusional disorderdelusionsmorphometryschizophrenia

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • Persecutory delusions are a common symptom in schizophrenia (F20) and delusional disorder (F22.0).
  • Understanding the neurobiological underpinnings of delusions is crucial for developing targeted treatments.
  • Previous research has shown varied structural brain abnormalities in psychotic disorders.

Purpose of the Study:

  • To investigate structural brain differences in patients with persecutory delusions compared to healthy controls.
  • To examine cortical thickness, subcortical volumes, hippocampal subfields, and brainstem structures.
  • To analyze findings within the transnosological model of delusions.

Main Methods:

  • Structural magnetic resonance imaging (MRI) was used.
  • Analysis included cortical gray matter thickness, volumes of subcortical structures, hippocampal subfields, and brainstem regions.
  • Comparison was made between patients with schizophrenia/delusional disorder and mentally healthy subjects.

Main Results:

  • Patients exhibited decreased cortical gray matter thickness in multiple regions.
  • Reduced volumes were observed in the left thalamus and specific hippocampal subfields.
  • No significant alterations were found in brainstem structures.

Conclusions:

  • Structural brain abnormalities, particularly in cortical and subcortical regions, are associated with persecutory delusions.
  • The findings support a transnosological perspective, suggesting shared neurobiological mechanisms across different delusional disorders.
  • Further research is warranted to explore the functional implications of these structural changes.