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Updated: Aug 2, 2026

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
Published on: September 17, 2012
The role of protein stability in the cell cycle and cancer
1Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA. selledge@bcm.tmc.edu
Abstract:
In addition to the examples mentioned above, other important regulators of cell proliferation such as cyclin D, cyclin E, p21, p27 are all potentially controlled by ubiquitin-mediated proteolysis. In several of these, phosphorylation has been shown to play a role in targeting the proteins for degradation. It remains to be seen how important the SCF pathway and ubiquitin-mediated proteolysis, in general, will become in cancer research. However, it appears that we have only just scratched the surface on the role of these pathways in the control of important regulatory genes. We suspect there will be much more to come from analysis of these fascinating pathways.
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