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Related Experiment Videos

Tianeptine therapy for depression in the elderly

J Saiz-Ruiz1, J M Montes, E Alvarez

  • 1Hospital Ramón y Cajal, Madrid, Spain. jeronimo.saiz@hrc.es

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|June 3, 1998
PubMed
Summary

This study found that tianeptine, a novel antidepressant, effectively treated depression in elderly patients. The medication demonstrated significant symptom reduction and was well-tolerated, with minimal side-effects in this population.

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Area of Science:

  • Geriatric Psychiatry
  • Pharmacology

Background:

  • Depression is common in the elderly, presenting diagnostic and treatment challenges.
  • Tianeptine offers a novel antidepressant mechanism, distinct from SSRIs, with demonstrated efficacy and safety.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of tianeptine in elderly patients with depressive symptoms.
  • To assess the impact of tianeptine on anxiety and cognitive function in this demographic.

Main Methods:

  • An open-label, 3-month, multicenter study involving 63 elderly patients (mean age 68.8 years) with major depression or dysthymia.
  • Patients received tianeptine 25 mg daily.
  • Depressive symptoms were assessed using the Montgomery and Asberg Depression Rating Scale.

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Main Results:

  • Significant reduction in Montgomery and Asberg Depression Rating Scale scores by day 14 (p < 0.01), with a 76.7% response rate.
  • 43 patients (68.2%) completed the study without dropouts due to side-effects.
  • Improvements noted in anxiety and cognitive performance; only 11.7% experienced side-effects, with no safety parameter changes.

Conclusions:

  • Tianeptine is an effective and well-tolerated antidepressant treatment for elderly patients.
  • The study supports tianeptine's utility in managing geriatric depression, anxiety, and cognitive deficits.