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[Prognostic value of E-cadherin expression in hepatocellular carcinoma]
S Garcia1, F Martini, C De Micco
1Service d'Anatomie et Cytologie Pathologiques, Faculté de médecine, Marseille.
Abstract:
Expression of E-cadherin (E-cad) was investigated immunohistologically in 91 cases of operated hepatocellular carcinomas. An alteration of E-cad immunodetection was found in 56% of tumours. These alterations were correlated with histopathologic features of prognostic value including tumour size (> 3 cm), high nuclear grade and mitotic index. Patients with down-regulated E-cad expression had statistically significant shorter survival than the others. Although E-cad immunodetection was an independent prognostic factor, the Cox multivariate analysis showed that its prognostic value was low when compared to other prognostic factors.