Related Experiment Videos
[Determination of DNA content in salivary gland tumors]
1Unidad de Anatomía Patológica-Citopatología Hospital de Temuco, Chile.
Background:
DNA content determination is a useful tool in the characterization of different malignant tumors.
Aim:
To measure DNA content in cells of salivary gland tumors as adjunct to histological diagnosis, correlating morphologic and biological features of these tumors.
Material And Methods:
From the archives of the Pathology service of a general hospital, 21 salivary gland tumors, 15 pleomorphic adenomas, 3 mucoepidermoid carcinomas and 3 cystic adenoid carcinomas were selected. DNA content was determined in the histological samples using a flow cytometric DNA analysis.
Results:
All pleomorphic adenomas had a normal or diploid DNA content. Fifty percent of malignant tumors had an aneuploid DNA content (1 mucoepidermoid carcinoma and 2 cystic adenoid carcinomas).
Conclusions:
DNA determination may help in the histological diagnosis of salivary gland tumors. The presence of aneuploidy suggests malignity.