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Bone marrow and peripheral blood involvement in mantle cell lymphoma
P L Cohen1, P J Kurtin, K A Donovan
1Division of Hematopathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
British Journal of Haematology
|June 3, 1998
Summary
Mantle cell lymphoma commonly affects peripheral blood and bone marrow. Diagnosis requires morphology, immunophenotyping, and tissue biopsy, as involvement patterns vary but do not significantly impact survival.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma.
- Understanding the extent and patterns of MCL involvement in peripheral blood and bone marrow is crucial for diagnosis and prognosis.
Purpose of the Study:
- To review peripheral blood smears, bone marrow aspirates, and biopsies in patients with mantle cell lymphoma.
- To evaluate the diagnostic utility and prognostic implications of peripheral blood and bone marrow involvement in MCL.
Main Methods:
- Retrospective review of morphologic, phenotypic, and molecular genetic data from 46 MCL patients.
- Analysis of peripheral blood, bone marrow aspirate, and bone marrow biopsy findings.
- Correlation of disease involvement with patient survival.
Main Results:
- Mantle cell lymphoma cells were detected in peripheral blood in 77% of patients.
- Bone marrow involvement was high: 83% in aspirates and 91% in biopsies, with various patterns (nodular, interstitial, paratrabecular, diffuse).
- No statistically significant difference in survival was observed between patients with or without peripheral blood involvement, or based on the extent of bone marrow involvement.
Conclusions:
- Mantle cell lymphoma frequently involves the peripheral blood and bone marrow.
- The appearance of MCL in these sites is variable.
- Diagnosis requires a combination of morphology, immunophenotyping, and tissue biopsy (preferably not bone marrow).