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Related Experiment Videos

Variations in ocular pressure during menstrual cycle

I A Qureshi1, X R Xi, X D Wu

  • 1Department of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|June 4, 1998
PubMed
Summary

This study found that while intraocular pressure (IOP) slightly fluctuates during the menstrual cycle, these changes are not statistically significant. Therefore, menstrual cycle variations do not impact glaucoma diagnosis.

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Area of Science:

  • Ophthalmology
  • Gynecology
  • Endocrinology

Background:

  • Intraocular pressure (IOP) is a critical factor in glaucoma diagnosis and management.
  • Hormonal fluctuations throughout the menstrual cycle may potentially influence physiological parameters, including IOP.

Purpose of the Study:

  • To investigate the potential correlation between specific days of the menstrual cycle and variations in intraocular pressure.
  • To determine if menstrual cycle phase influences IOP measurements in women.

Main Methods:

  • A cohort of 1,459 women had their intraocular pressure (IOP) measured.
  • The number of days since the last menstrual period was recorded for each participant.
  • Goldmann applanation tonometry was used for all IOP measurements.

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Main Results:

  • Mean IOP exhibited minor variations across different days of the menstrual cycle.
  • The highest mean IOP was observed between days 20-22, with a secondary peak between days 13-15.
  • The lowest mean IOP was recorded between days 16-19.
  • Statistical analysis revealed that these IOP differences were insignificant.

Conclusions:

  • Intraocular pressure demonstrates slight variations throughout the menstrual cycle.
  • These fluctuations are statistically insignificant and do not pose a risk for misdiagnosis of glaucoma.
  • Menstrual cycle phase is unlikely to be a confounding factor in routine IOP assessments for glaucoma.