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Updated: Aug 22, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
[Meningitis caused by enterovirus in a pediatric hospital: experience in 1996]
S Valdezate1, F Mesa, J R Otero
1Unidad de Virología, Hospital 12 de Octubre, Madrid.
Background:
To know the incidence, etiology to the serotype level and epidemiological characteristics of cases of enteroviral meningitis diagnosed in a pediatric emergency service in 1996.
Methods:
Inoculation of conventional cell cultures with samples of cerebrospinal fluid (CSF), throat swabs and stools taken from children with clinically suspected meningitis.
Results:
Enterovirus was cultured from 17 of 65 (26.2%) CSF samples with pleocytosis (more than 10 cells/mm3) and from 12 of 268 (4.5%) biologically normal samples. The identified isolates of CSF (20 of 29) were: ECHO 30 (9), ECHO 11 (7), ECHO 9 (3) and ECHO 7 (1). Most (79%) isolates were obtained between March and June.
Conclusions:
Enteroviral meningitis was apparently more common in spring, although the number of samples was significantly lower during the summer months. The clinical cases were sporadic, due to at least four echoviruses serotypes. The isolation of enterovirus from CSF without pleocytosis is not exceptional (41% of our isolates).
Insights
Enteroviral meningitis occurred more frequently in spring, caused by multiple echovirus serotypes. Enteroviruses were isolated from cerebrospinal fluid (CSF) even without pleocytosis, indicating broader diagnostic considerations.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Epidemiology
Context:
- Enteroviral meningitis is a significant concern in pediatric populations.
- Understanding serotype distribution and seasonal patterns is crucial for public health.
- Previous studies have not fully elucidated the epidemiological characteristics in this specific setting.
Purpose:
- To determine the incidence, serotype-level etiology, and epidemiological features of enteroviral meningitis in a pediatric emergency service in 1996.
Summary:
- Enterovirus was cultured from 26.2% of CSF samples with pleocytosis and 4.5% of those without.
- ECHO 30, ECHO 11, ECHO 9, and ECHO 7 were the predominant serotypes identified.
- Most enteroviral isolates (79%) were detected between March and June, suggesting a spring seasonality.
Impact:
- This study highlights the importance of considering enteroviral meningitis, even in cases lacking typical cerebrospinal fluid pleocytosis.
- Findings contribute to the understanding of enteroviral meningitis epidemiology in children.
- The data can inform public health strategies for managing enteroviral infections.
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