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Updated: Jul 10, 2026

Methodology for Accurate Detection of Mitochondrial DNA Methylation
Published on: May 20, 2018
Linear mitochondrial genomes: 30 years down the line
J Nosek1, L Tomáska, H Fukuhara
1Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
Abstract:
At variance with the earlier belief that mitochondrial genomes are represented by circular DNA molecules, a large number of organisms have been found to carry linear mitochondrial DNA. Studies of linear mitochondrial genomes might provide a novel view on the evolutionary history of organelle genomes and contribute to delineating mechanisms of maintenance and functioning of telomeres. Because linear mitochondrial DNA is present in a number of human pathogens, its replication mechanisms might become a target for drugs that would not interfere with replication of human circular mitochondrial DNA.
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