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Related Experiment Videos

Excess dietary protein can adversely affect bone

U S Barzel1, L K Massey

  • 1Division of Endocrinology and Metabolism, Department of Medicine, Montefiore Medical Center and The Albert Einstein College of Medicine, Bronx, NY 10467, USA.

The Journal of Nutrition
|June 18, 1998
PubMed
Summary
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High protein diets generate acid, leading to bone calcium loss. Adding alkali-rich foods or supplements can buffer this acid, protecting bone health by reducing calcium excretion.

Area of Science:

  • Nutrition Science
  • Bone Metabolism
  • Renal Physiology

Background:

  • The typical American diet is protein-rich and low in fruits/vegetables, creating a significant acid load.
  • This dietary acid load is primarily composed of sulfates and phosphates, challenging the body's acid-base balance.
  • Kidneys respond by excreting net acid, ammonium, and titratable acid, while the skeleton releases buffers through bone resorption.

Purpose of the Study:

  • To investigate the impact of dietary acid load on bone metabolism.
  • To determine the effect of exogenous buffers on acid excretion and calcium balance.
  • To evaluate the role of alkali-rich foods in mitigating the adverse effects of high-protein diets on bone.

Main Methods:

  • Analysis of dietary protein's potential acid load and its acidogenic effect.

Related Experiment Videos

  • Assessment of the impact of adding exogenous buffers (chemical salts, fruits, vegetables) to high-protein diets.
  • Measurement of urine and blood parameters including net acid excretion, calciuria, and bone resorption markers.

    • Main Results:

    • Diets high in acid-ash proteins significantly increase calcium loss (calciuria) due to acid load.
    • Addition of alkali buffers (fruits, vegetables, potassium-rich foods, or chemical salts) reduces urine acidity and net acid excretion.
    • Exogenous buffers decrease calciuria, potentially halting bone resorption and promoting bone accretion.

    Conclusions:

    • Excessive dietary protein, particularly from high potential renal acid load foods, negatively impacts bone health.
    • Alkali buffers, from sources like fruits and vegetables, are crucial for reversing acid-induced calcium loss.
    • Buffering high-protein diets with alkali-rich foods or supplements is essential for maintaining bone integrity.