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Transcription regulatory region analysis using signal detection and fuzzy clustering
L Pickert1, I Reuter, F Klawonn
1Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
Motivation:
Presently available programs for the recognition of potential transcription factor binding sites in genomic sequences generally yield a huge amount of output. These output lists have to be filtered to obtain biologically significant elements, which is highly laborious work to be done manually.
Results:
We developed a strategy for systematic verification and improvement of the underlying profiles, and for their contextual analysis by a fuzzy clustering approach using non-redundant libraries of search profiles as a prerequisite.
Availability:
The tools mentioned in the paper are available upon request.
Contact:
ewi@gbf.de