Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Angiogenesis and neoangiogenesis]

C Savona1, S Javerzat, C Perollet

  • 1Laboratoire des facteurs de croissance et de la différenciation cellulaire Université Bordeaux I, Talence.

La Revue Du Praticien
|June 9, 1998
PubMed
Summary

Angiogenesis, the formation of new blood vessels, is vital in development and disease. Understanding key inducers like FGF-2 and VEGF can lead to new treatments for related conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for RNA integrity in fresh-frozen renal cancer samples from routine practice (UroCCR 9).

The French journal of urology·2026
Same author

The strange Microenvironment of Glioblastoma.

Revue neurologique·2023
Same author

A model of guided cell self-organization for rapid and spontaneous formation of functional vessels.

Science advances·2019
Same author

Ligand activation induces different conformational changes in CXCR3 receptor isoforms as evidenced by plasmon waveguide resonance (PWR).

Scientific reports·2017
Same author

INHIBITION OF ERN1 SIGNALING ENZYME AFFECTS HYPOXIC REGULATION OF THE EXPRESSION OF E2F8, EPAS1, HOXC6, ATF3, TBX3 AND FOXF1 GENES IN U87 GLIOMA CELLS.

Ukrainian biochemical journal·2015
Same author

[Significance of the results of surgery in treatment of pulmonary tuberculosis].

Schweizerische Zeitschrift fur Tuberkulose. Revue suisse de la tuberculose. Rivista svizzera della tubercolosi·2014

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Pathology

Context:

  • Angiogenesis is crucial for embryogenesis, adult tissue repair, and pathological processes like tumor growth and metastasis.
  • Key regulators of neovascularization include fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF).
  • Extracellular matrix components and angiostatic factors modulate the activity of these growth factors.

Purpose:

  • To elucidate the fundamental mechanisms governing angiogenesis.
  • To identify key molecular players in neovascularization.
  • To provide a basis for developing novel therapeutic strategies.

Summary:

  • Angiogenesis, the development of new capillaries, is essential in embryogenesis, wound healing, and diseases such as cancer.
  • Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are primary inducers of this process.
  • The biological activity of FGF-2 and VEGF is tightly regulated by the extracellular matrix and inhibitory factors.

Impact:

  • Enhanced understanding of angiogenesis molecular mechanisms.
  • Potential for developing new therapeutic agents targeting neovascularization.
  • Improved treatment strategies for angiogenesis-related pathologies.

Related Experiment Videos