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Published on: November 12, 2015
Pharyngeal isolations of adenovirus 31 from a family population
Abstract:
During a 14-month period in 1965 and 1966, adenovirus type 31 was isolated from 26 pharyngeal swabs obtained on a routine schedule from children and adults during a study of respiratory viruses among members of a family population. Eighteen isolations were made in a four-day period, seven within the preceding five months, and the last, eight months earlier. A significant association between the isolation of adenovirus 31 and respiratory or gastrointestinal illnesses was not demonstrable. Limited tests demonstrated neutralizing antibody increases in a few paired sera of infected adults. The virus is antigenically related to adenoviruses 12 and 18 and is capable of inducing soft tissue tumors in mice.
Insights
Adenovirus type 31 was frequently isolated from individuals over 14 months. However, no clear link was found between adenovirus 31 and illness, though it can cause tumors in mice.
Area of Science:
- Virology
- Epidemiology
Background:
- Adenovirus type 31 (human adenovirus C) is a significant respiratory pathogen.
- Understanding its prevalence and association with illness is crucial for public health.
Purpose of the Study:
- To investigate the isolation frequency of adenovirus type 31.
- To determine the association between adenovirus 31 and respiratory or gastrointestinal illnesses.
- To assess antibody responses in infected individuals.
Main Methods:
- Pharyngeal swabs collected from a family population over 14 months (1965-1966).
- Virus isolation and identification.
- Serological tests for antibody increases.
Main Results:
- Adenovirus type 31 was isolated from 26 pharyngeal swabs.
- Eighteen isolations occurred within a four-day period, indicating potential clustering.
- No significant association was found between adenovirus 31 isolation and reported illnesses.
- Neutralizing antibody increases were observed in a few paired sera from infected adults.
Conclusions:
- Adenovirus type 31 circulated within the studied population.
- The study did not establish a direct link between adenovirus 31 and symptomatic illness.
- Adenovirus 31 shows antigenic relation to types 12 and 18 and oncogenic potential in mice.
