Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Validating new toxicology tests for regulatory acceptance

Zeiger1, Stokes

  • 1Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA.

Regulatory Toxicology and Pharmacology : RTP
|June 10, 1998
PubMed
Summary

New toxicology tests require validation to ensure reliability and relevance for safety evaluations. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) facilitates this process for regulatory acceptance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Importance of Nourishment in Fever.

Iowa medical journal·2023
Same author

Quickness of Pulse after Fever.

Iowa medical journal·2023
Same author

Gastric Ulcers and Perforating Ulcer of Duodenum after a Burn.

Edinburgh medical journal·2018
Same author

The enlightened secrets across the ocean.

Trends in microbiology·2000
Same author

Serial lactate measurements during surgery involving deep hypothermic circulatory arrest

Paediatric anaesthesia·2000
Same author

Making High-level Queries on Diverse Genome Data: A Structured Genome Document Database System Based on GXML and GQL.

Genome informatics. Workshop on Genome Informatics·2000

Area of Science:

  • Toxicology
  • Regulatory Science
  • Biotechnology

Background:

  • Acceptance of new toxicology tests hinges on validation for safety evaluation.
  • Validation ensures a test's reliability (reproducibility) and relevance (mechanistic link to health effects).
  • Regulatory and industrial stakeholders require confidence in new testing methods.

Purpose of the Study:

  • To outline the essential components of toxicology test validation.
  • To introduce the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM).
  • To describe ICCVAM's role in coordinating the evaluation and adoption of alternative testing methods.

Main Methods:

  • Validation assesses operational characteristics: reliability and relevance.
  • Reliability is determined by reproducibility.

Related Experiment Videos

  • Relevance is judged by mechanistic links to health outcomes and predictive ability.

    • Main Results:

    • The U.S. government established ICCVAM to coordinate validation efforts.
    • ICCVAM provides guidance on test development, validation, and acceptance criteria.
    • ICCVAM facilitates interagency coordination and external communication on test method validation.

    Conclusions:

    • Robust validation is critical for the acceptance of new toxicology tests.
    • ICCVAM plays a key role in standardizing and promoting validated alternative methods.
    • Effective validation processes build confidence among users and decision-makers.