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Yeast carbon catabolite repression

J M Gancedo1

  • 1Instituto de Investigaciones Biomédicas, Unidad de Bioquímica y Genética de Levaduras, CSIC, 28029 Madrid, Spain. jmgancedo@iib.uam.es

Microbiology and Molecular Biology Reviews : MMBR
|June 10, 1998
PubMed
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Catabolite repression is a cellular process where glucose inhibits the use of other sugars. The protein kinase Snf1 (Sucrose non-fermenting 1) is crucial for regulating this process, acting as a central switch.

Area of Science:

  • * Molecular biology
  • * Biochemistry
  • * Genetics

Background:

  • * Catabolite repression governs the utilization of alternative carbon sources in response to glucose presence.
  • * Sugars trigger signaling pathways that alter protein conformations, influencing gene expression.
  • * Diverse regulatory circuits exist, but the Snf1/Cat1 protein kinase is a common component.

Purpose of the Study:

  • * To elucidate the regulatory mechanisms of catabolite repression.
  • * To understand the role of Snf1/Cat1 in integrating different regulatory circuits.
  • * To identify the factors influencing Snf1 activity in response to glucose.

Main Methods:

  • * Analysis of gene transcription in response to various sugars.
  • * Investigation of protein kinase and phosphatase activities.

Related Experiment Videos

  • * Study of mutant strains lacking specific regulatory proteins (Grr1/Cat80, Hxk2, Glc7).

    • Main Results:

    • * Snf1/Cat1 is a central regulatory element shared across different catabolite repression circuits.
    • * Snf1 activity is inhibited by glucose, likely through dephosphorylation.
    • * Snf1 remains active in mutants lacking Grr1/Cat80, Hxk2, or the Glc7 phosphatase complex.
    • * Snf1 relieves repression by the Mig1 complex and is required for Adr1 function.

    Conclusions:

    • * Catabolite repression involves complex, interconnected regulatory pathways.
    • * Snf1 plays a pivotal role in mediating glucose's effect on alternative carbon source utilization.
    • * Further research is needed to fully map the integration of these regulatory elements.