Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal coincidence detection by voltage-sensitive electrical synapses

D H Edwards1, S R Yeh, F B Krasne

  • 1Department of Biology, Georgia State University, Atlanta, GA 30302-4010, USA.

Proceedings of the National Academy of Sciences of the United States of America
|June 17, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.

American journal of physiology. Cell physiology·2015
Same author

The organization of escape behaviour in the crayfish.

The Journal of experimental biology·2010
Same author

Molecular and epidemiological analysis of methicillin-resistant Staphylococcus aureus otorrhoea: hospital- or community-acquired?

The Journal of laryngology and otology·2010
Same author

Neuromechanical simulation of the locust jump.

The Journal of experimental biology·2010
Same author

A CMOS neuroelectronic interface based on two-dimensional transistor arrays with monolithically-integrated circuitry.

Biosensors & bioelectronics·2008
Same author

Static magnetic field expose enhances neurotransmission in crayfish nervous system.

International journal of radiation biology·2008

Electrical synapses provide precise coincidence detection, crucial for neural functions. Synchronous inputs are summed, while delayed inputs are attenuated, enabling rapid responses to stimuli.

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Computational Neuroscience

Background:

  • Coincidence detection is vital for neural processes like Hebbian learning and sensory localization.
  • Rectifying electrical synapses are known to facilitate communication between neurons.

Purpose of the Study:

  • To investigate how rectifying electrical synapses contribute to precise coincidence detection.
  • To elucidate the mechanisms underlying temporal summation in neural circuits.

Main Methods:

  • Studied the function of rectifying electrical synapses in crayfish lateral giant neurons.
  • Analyzed synaptic current dynamics under synchronous and asynchronous input conditions.

Main Results:

  • Electrical synapses naturally perform precise coincidence detection.

Related Experiment Videos

  • Synchronous inputs generate large excitatory postsynaptic potentials, while delayed inputs are significantly reduced.
  • These mechanisms explain temporal summation properties observed in crayfish escape responses.

    • Conclusions:

    • Rectifying electrical synapses offer a mechanism for precise coincidence detection.
    • This mechanism may be widespread in the mammalian central nervous system.
    • Coincidence detection via electrical synapses plays a role in sensory processing and motor control.