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Toxicological evaluation of sobatum
1Toxicology Group, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, India.
Cancer Letters
|June 10, 1998
Summary
The anticancer agent sobatum, derived from Solanum trilobatum, demonstrated no acute or subacute toxicity in mice. This study confirms sobatum
Area of Science:
- Pharmacology
- Toxicology
- Natural Products Chemistry
Background:
- Solanum trilobatum is a plant with potential medicinal properties.
- Sobatum, identified as beta-sitosterol, has shown anticancer activity.
- Evaluating the safety profile of potential therapeutic agents is crucial.
Purpose of the Study:
- To assess the acute and subacute toxicity of sobatum.
- To investigate the effects of sobatum on antioxidant enzymes.
- To determine histopathological changes associated with sobatum administration.
Main Methods:
- Acute toxicity testing involved single-dose administration in mice.
- Subacute toxicity studies included daily exposure to evaluate target organs and effects.
- Blood parameters, antioxidant enzyme activity, and histopathology were analyzed.
Main Results:
- Sobatum did not induce toxicity symptoms or mortality in acute or subacute tests.
- No significant changes were observed in blood parameters or antioxidant enzyme levels.
- Histopathological examination revealed no gross abnormalities or lesions in treated animals.
Conclusions:
- Sobatum is safe and does not exhibit acute or subacute toxicity.
- The anticancer agent sobatum does not adversely affect antioxidant enzyme synthesis.
- Sobatum represents a potentially safe therapeutic agent for further investigation.