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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Candida laryngitis appearing as leukoplakia and GERD
1The Ohio State University, Department of Otolaryngology, The Ohio State University Voice Center, USA.
Summary
Reflux laryngopharyngitis symptoms can mimic fungal infections of the larynx. Consider mycotic laryngitis in patients with persistent dysphonia, even if immunocompetent.
Area of Science:
- Otolaryngology
- Mycology
- Gastroenterology
Background:
- Reflux laryngopharyngitis presents with characteristic laryngeal symptoms, but mucosal changes are not unique to reflux.
- Equivocal responses to standard reflux treatments necessitate exploring alternative diagnoses.
Observation:
- Mycotic laryngitis, particularly laryngeal candidiasis, can mimic reflux laryngopharyngitis.
- Physical findings like erythema and leukoplakia are common in both conditions.
- Predisposing factors include immunosuppression, radiation, antibiotics, and corticosteroid use.
Findings:
- Diagnosis relies on laryngeal biopsy and special staining to detect fungal hyphae.
- Mycotic laryngitis can affect both immunocompromised and immunocompetent individuals.
- Dysphonia in immunocompromised patients warrants consideration of fungal infections.
Implications:
- Early consideration of mycotic laryngitis is crucial for accurate diagnosis and treatment.
- Effective management of laryngeal mycoses may require prolonged antifungal therapy.
- Distinguishing fungal from reflux-induced laryngitis is key to appropriate patient care.
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