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[The function of the thyroid and thyrotropic function in patients with chronic ischemic heart disease and rhythm
Insights
Thyroid hormone levels in chronic heart disease patients with arrhythmias show varied changes. Triiodothyronine (T3) and thyroxine (T4) levels were altered in specific arrhythmia types, suggesting a link between thyroid function and heart disease.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Chronic heart disease (CHD) is frequently associated with arrhythmias.
- Thyroid hormones play a crucial role in cardiovascular function.
- The relationship between specific arrhythmias and thyroid hormone levels in CHD patients requires further elucidation.
Purpose of the Study:
- To investigate blood levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) in patients with chronic heart disease and different types of arrhythmias.
- To identify potential correlations between specific arrhythmias and thyroid hormone profiles in this patient cohort.
Main Methods:
- Blood samples were collected from 119 patients with chronic heart disease (62 with exercise-induced angina, 57 with cardiosclerosis).
- Patients presented with various arrhythmias: extrasystolic arrhythmia (n=58), permanent form cardiac fibrillation (n=38), and cardiac fibrillation with ventricular arrhythmia (n=23).
- Thyroid hormone levels (TSH, T3, T4) were measured using immunoradiometric assay.
Main Results:
- In extrasystolic arrhythmia and permanent form cardiac fibrillation, basal TSH levels remained normal, with reduced T3 and augmented T4 observed in cardiac fibrillation.
- In permanent form cardiac fibrillation associated with ventricular arrhythmia, TSH levels decreased, while T3 and T4 levels showed no significant changes.
- Post-treatment, T3 levels tended to increase in patients with extrasystolic arrhythmia.
Conclusions:
- Specific alterations in thyroid hormone levels (T3 and T4) are associated with different types of arrhythmias in patients with chronic heart disease.
- These findings suggest a complex interplay between thyroid dysfunction and cardiac arrhythmias in the context of chronic heart disease.
- Further research is warranted to explore the clinical implications and potential therapeutic strategies targeting thyroid hormone modulation in these patients.
Abstract:
Measured in 119 patients with chronic heart disease (exercise-induced angina in 62, cardiosclerosis in 57 cases) presenting with arrhythmias (extrasystolic arrhythmia, permanent form cardiac fibrillation, association of cardiac fibrillation with ventricular arrhythmia, with n = 58, 38, 23 respectively) were blood levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxin (T4) using immunoradiometric assay. In extrasystolic arrhythmia, permanent form cardiac fibrillation, there were no deviations from the norm in the basal TSH blood levels, reduction in (T3) as well as augmentation of (T4) in cardiac fibrillation. With permanent form cardiac fibrillation associated with ventricular arrhythmia the TSH blood level got decreased, the (T3) and (T4) content undergoing no changes The posttreatment blood content of (T3) tended to augment in extrasystolic arrhythmia.