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Factor V Leiden mutation as a risk factor for recurrent pregnancy loss
P M Ridker1, J P Miletich, J E Buring
1Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Annals of Internal Medicine
|June 13, 1998
Summary
Women with the factor V Leiden mutation have a higher risk of recurrent pregnancy loss. This inherited coagulation defect is linked to unexplained pregnancy losses, suggesting a potential role in their development.
Area of Science:
- Reproductive Medicine
- Hematology
- Genetics
Background:
- Recurrent pregnancy loss (RPL) is a significant concern in reproductive medicine.
- Hypercoagulability, a state of increased blood clotting, is a potential underlying cause of RPL.
- Factor V Leiden mutation is a common inherited thrombophilia.
Purpose of the Study:
- To investigate the association between the factor V Leiden mutation and recurrent pregnancy loss.
- To determine if this inherited coagulation defect increases the risk of RPL.
Main Methods:
- A case-control study was conducted.
- Case-patients included 113 women with recurrent spontaneous abortion.
- Controls comprised 437 postmenopausal women with successful pregnancies and no history of loss.
Main Results:
- The prevalence of factor V Leiden mutation was significantly higher in women with RPL (8.0%) compared to controls (3.7%).
- An odds ratio of 2.3 indicated an increased risk of RPL associated with the mutation.
- In women with three or more pregnancy losses, the mutation prevalence was 9.0%, showing a 2.2-fold increased risk.
Conclusions:
- The findings support the hypothesis that factor V Leiden mutation contributes to unexplained recurrent pregnancy loss.
- Factor V Leiden mutation is a potential risk factor for RPL in certain patient populations.
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