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Zinc may regulate serum leptin concentrations in humans

C S Mantzoros1, A S Prasad, F W Beck

  • 1Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Journal of the American College of Nutrition
|June 17, 1998
PubMed
Summary

Zinc status impacts leptin levels in humans. Supplementation of zinc increased leptin, potentially by boosting interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) production.

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Area of Science:

  • Human physiology
  • Nutritional science
  • Endocrinology

Background:

  • Leptin regulates energy balance, appetite, and metabolism.
  • Zinc is crucial for appetite regulation.
  • The interplay between zinc status and the leptin system requires investigation.

Purpose of the Study:

  • To investigate the relationship between zinc status and the human leptin system.
  • To determine how dietary zinc affects serum leptin levels.

Main Methods:

  • Nine healthy men with diet-induced marginal zinc deficiency were studied.
  • Leptin levels were measured before and after zinc supplementation.

Main Results:

  • Zinc restriction led to decreased leptin levels.

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  • Zinc supplementation in deficient subjects elevated circulating leptin.
  • Supplementation also increased interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) production.

    • Conclusions:

    • Zinc status may influence serum leptin concentrations.
    • Increased IL-2 and TNF-alpha production could mediate the effect of zinc on leptin.