Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroimmunomodulation by macrophage migration inhibitory factor (MIF)

R Bucala1

  • 1Laboratory of Medical Biochemistry, Picower Institute for Medical Research, Manhasset, New York 10030, USA. rbucala@picower.edu

Annals of the New York Academy of Sciences
|June 18, 1998
PubMed
Summary

Macrophage migration inhibitory factor (MIF) acts as an endogenous hormone to counteract glucocorticoid effects in the immune system. This discovery offers new therapeutic strategies for autoimmune and inflammatory conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MIF is a common genetic determinant of COVID-19 symptomatic infection and severity.

QJM : monthly journal of the Association of Physicians·2022
Same author

Managing COVID-19 going forward-the lessons from history.

QJM : monthly journal of the Association of Physicians·2022
Same author

A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.

American journal of physiology. Lung cellular and molecular physiology·2018
Same author

Lipid and lipoprotein oxidation: basic mechanisms and unresolved questions in vivo.

Redox report : communications in free radical research·2016
Same author

MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis.

Oncogene·2016
Same author

Macrophage migration inhibitory factor promotes eosinophil accumulation and tissue remodeling in eosinophilic esophagitis.

Mucosal immunology·2015

Area of Science:

  • Immunology
  • Endocrinology
  • Cell Biology

Background:

  • Glucocorticoids are key regulators of the host's stress response, influencing immune function.
  • Macrophage migration inhibitory factor (MIF) was initially identified as a T lymphocyte factor inhibiting macrophage migration.
  • MIF is released by macrophages and T cells in response to glucocorticoids and inflammatory stimuli.

Purpose of the Study:

  • To elucidate the role of MIF as an endogenous hormone counterregulating glucocorticoid action.
  • To understand how MIF influences the immune response during infection and tissue invasion.
  • To explore the potential of anti-MIF therapies for autoimmune and inflammatory diseases.

Main Methods:

  • Isolation and structural identification of MIF from anterior pituitary cells.

Related Experiment Videos

  • Investigating the release of MIF by immune cells (macrophages and T cells) under specific stimuli.
  • Analyzing the functional interaction between MIF and glucocorticoids in immune regulation.

    • Main Results:

    • MIF acts as an endogenous hormone counterbalancing glucocorticoid immunosuppression.
    • Secreted MIF overrides the inhibitory effects of steroids on macrophage and T-cell cytokine production.
    • MIF plays a crucial role in initiating and controlling the host's immune response.

    Conclusions:

    • MIF is a critical mediator in the immune system, opposing glucocorticoid-induced immunosuppression.
    • Targeting MIF offers a promising therapeutic avenue to enhance anti-inflammatory effects and reduce steroid dependency.
    • Understanding MIF's function provides insights into managing autoimmune and inflammatory conditions.