The reactivity of the cardiovascular system and immunomodulation by catecholamines in juvenile chronic arthritis

Juvenile chronic arthritis is associated with clinical symptoms indicating that there is a dysregulation of the sympathetic nervous system (SNS). Our data show that patients with juvenile chronic arthritis have an altered function of the SNS associated with increased central noradrenergic outflow, presumably leading to increased vasoconstriction, resulting in a decreased response to an orthostatic stressor. We also investigated the consequences of the altered reactivity of SNS for the reactivity of the immune system to mediators of the sympathetic nervous system and to glucorticoids. It appeared that leukocytes of these patients have an altered response to catecholamines. Triggering of the beta 2-adrenergic receptor leads to reduced cAMP responses that are due to the higher rate of cAMP degradation. In addition, catecholamines induce the production of IL-6 by leukocytes of these patients, via triggering of alpha 1-adrenergic receptors. Healthy controls do not express functional alpha 1-adrenergic receptors.