Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

G protein subunits and cell proliferation

N Dhanasekaran1, M V Prasad

  • 1Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. danny@sgil.fels.temple.edu

Biological Signals and Receptors
|June 18, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of dietary supplementation of organic and inorganic Se on performance and antioxidant response in commercial broiler chickens.

British poultry science·2022
Same author

Studies on induced mutants with reference to species relationships in some tetraploid Triticums.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2014
Same author

Proliferation-specific genes activated by Galpha(12): a role for PDGFRalpha and JAK3 in Galpha(12)-mediated cell proliferation.

Cell biochemistry and biophysics·2007
Same author

Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.

Oncogene·2005
Same author

Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12.

Oncogene·2005
Same author

Engineered Saccharomyces cerevisiae strain BioS-1, for the detection of water-borne toxic metal contaminants.

Biotechnology and bioengineering·2005

G proteins, crucial for serpentine receptor signaling, involve both alpha and beta gamma subunits in regulating cell growth and differentiation. These subunits coordinate cell proliferation via distinct pathways involving GTPases and kinases.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Biochemistry

Background:

  • G proteins (guanine nucleotide-binding proteins) are key signal transducers for serpentine receptors.
  • Both G protein alpha and beta gamma subunits regulate cellular functions.
  • Cellular responses mediated by G proteins are critical for cell growth and differentiation.

Purpose of the Study:

  • To review the signaling mechanisms by which G protein subunits regulate cell proliferation.
  • To highlight the distinct pathways utilized by G alpha and G beta gamma subunits.
  • To summarize the integrated network controlling cell proliferation.

Main Methods:

  • Review of recent studies on G protein signaling.
  • Analysis of data from constitutively activated G alpha mutants.

Related Experiment Videos

  • Examination of studies involving overexpression of G beta gamma subunits.

    • Main Results:

    • G alpha and G beta gamma subunits differentially regulate cell proliferation.
    • Distinct signaling pathways involving low molecular weight GTPases and protein kinases are implicated.
    • Cross-talk between these pathways contributes to coordinated cell proliferation.

    Conclusions:

    • G protein subunits play a significant role in cell proliferation control.
    • Understanding these diverse signaling mechanisms is crucial for comprehending cell growth regulation.
    • The integrated network of G protein signaling pathways provides a coordinated mechanism for cell proliferation.