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Expression and function of CD40 in rheumatoid arthritis synovium
C Sekine1, H Yagita, N Miyasaka
1Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Objective:
To determine the involvement of CD40 in chronic activation of rheumatoid arthritis (RA) synovial monocytes.
Methods:
CD40 expression on RA synovial monocytes was examined by immunostaining. Involvement of CD40 in tumor necrosis factor-alpha (TNF-alpha) secretion from RA synovial fluid mononuclear cells (SFMC) was examined by blocking with anti-CD40 antibody.
Results:
CD40 was expressed on RA synovial monocytes. TNF-alpha secretion from RA SFMC was enhanced by CD40 ligand stimulation. Spontaneous secretion of TNF-alpha from RA SFMC was inhibited by anti-CD40 antibody.
Conclusion:
CD40 was involved in the activation of RA synovial monocytes that leads to TNF-alpha production.