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Inhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile
M P Matousek1, J G Nedrud, W Cieplak
1Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Infection and Immunity
|June 25, 1998
Abstract:
Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT) were found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex complexes. Inhibition of antigen processing correlated with A subunit ADP-ribosyltransferase activity.