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Genetic and immunological host factors associated with susceptibility to HIV-1 infection
K A Buchacz1, D A Wilkinson, J F Krowka
1Department of Epidemiology, University of California, Berkeley, USA.
AIDS (London, England)
|June 20, 1998
Abstract:
The probability of HIV transmission depends on the interplay of many different factors related to infectiousness of the HIV-infected partner, susceptibility of the HIV-uninfected partner, and biological characteristics of HIV strains. Here, we review recent studies of host immunological and genetic factors which may affect susceptibility to HIV-1 infection. These factors are summarized in Table 1. We propose how to explore biological correlates of susceptibility to HIV-1 infection in epidemiological studies, discuss the strengths and limitations of this research, and address the implications for public health.