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Familial aggregation in frontotemporal dementia

M Stevens1, C M van Duijn, W Kamphorst

  • 1Department of Neurology, University Hospital Rotterdam, The Netherlands.

Neurology
|June 20, 1998
PubMed
Summary
This summary is machine-generated.

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Genetic factors significantly increase frontotemporal dementia (FTD) risk. FTD patients have earlier onset dementia in relatives, highlighting familial links.

Area of Science:

  • Neuroscience
  • Genetics
  • Epidemiology

Background:

  • Frontotemporal dementia (FTD) is a prevalent non-Alzheimer's dementia.
  • Familial occurrence of FTD is known, but its frequency remains unquantified.

Purpose of the Study:

  • To investigate the frequency of a positive family history of dementia in FTD patients.
  • To analyze the genetic-epidemiologic factors contributing to FTD.

Main Methods:

  • Nationwide genetic-epidemiologic study in the Dutch population (15 million).
  • Analyzed family history of dementia in 74 FTD patients and 561 age/gender-matched controls.

Main Results:

  • 38% of FTD patients had first-degree relatives with dementia before age 80 (vs. 15% controls).

Related Experiment Videos

  • FTD relatives showed a 22% risk of dementia before 80 (vs. 11% controls), with onset 11 years earlier.
  • FTD patients had higher ApoE4E4 genotype prevalence (7% vs. 2.3%) and 3.5x increased risk for dementia in first-degree relatives.

    • Conclusions:

    • Genetic factors play a significant role in a proportion of FTD cases.
    • FTD is associated with an earlier age of dementia onset in first-degree relatives.