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Persistent inflammatory response in stroke survivors

N B Beamer1, B M Coull, W M Clark

  • 1Department of Neurology, Arizona Health Sciences Center, Tucson 85724-5023, USA.

Neurology
|June 20, 1998
PubMed
Summary
This summary is machine-generated.

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Fibrinogen (FIB) remains elevated long after ischemic stroke, indicating a higher risk for future vascular events. Other acute-phase markers like C-reactive protein (CRP) and white blood cell (WBC) counts also show prolonged elevation in stroke survivors and at-risk patients.

Area of Science:

  • Biomedical research
  • Clinical neurology
  • Inflammation and vascular disease

Background:

  • Acute-phase markers are often elevated following ischemic stroke.
  • The duration of elevation and prognostic significance of these markers require further investigation.
  • Understanding these markers' behavior can inform risk stratification and management strategies for stroke patients.

Purpose of the Study:

  • To determine the persistence of acute-phase markers after ischemic stroke.
  • To investigate the relationship between marker levels and stroke risk factors, stroke mechanisms, and subsequent vascular events.
  • To compare marker levels in stroke patients, at-risk individuals, and healthy controls over time.

Main Methods:

  • Longitudinal study measuring fibrinogen (FIB), C-reactive protein (CRP), leukocytes (WBC), neutrophils (PMN), and cytokines in 136 stroke patients, 76 at-risk individuals, and 48 controls.

Related Experiment Videos

  • Measurements were taken at stroke onset and at 6 weeks, 6 months, and 1 year post-enrollment or until a vascular event.
  • Multivariate logistic analysis was used to identify predictors of new vascular events.

    • Main Results:

    • Fibrinogen (FIB) levels remained significantly elevated at 1 year in event-free stroke survivors compared to control groups.
    • Elevated FIB levels at baseline predicted new vascular events in stroke patients.
    • Leukocyte (WBC) and neutrophil (PMN) levels were chronically elevated in both stroke survivors and at-risk individuals compared to healthy subjects.

    Conclusions:

    • Fibrinogen (FIB) is a key acute-phase marker that remains elevated long-term after ischemic stroke.
    • Sustained elevation of FIB is associated with an increased risk of recurrent vascular events.
    • Chronic elevation of WBC and PMN levels is observed in stroke survivors and at-risk populations.