Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cefuroxime-induced encephalopathy

Y O Herishanu1, M Zlotnik, M Mostoslavsky

  • 1Department of Neurology, Soroka Medical Center and Goldman Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Neurology
|June 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CT imaging features of symptomatic and asymptomatic floating aortic thrombus.

Clinical radiology·2017
Same author

Transient immunosuppression: a bridge between infection and the atypical autoimmunity of Guillain-Barré syndrome?

Clinical and experimental immunology·2010
Same author

Acute viral hepatitis (C - genotype 6a and B) acquired during kidney transplantation by two patients and review of the literature.

Clinical nephrology·2009
Same author

Increased severity over generations of Charcot-Marie-Tooth disease type 1A.

Journal of neurology·2008
Same author

'Hyperacute' Guillain-Barré syndrome.

European neurology·2007
Same author

Co-morbidity of Emery-Dreifuss muscular dystrophy and a congenital myasthenic syndrome possibly affecting the phenotype in a large Bedouin kindred.

European journal of neurology·2007
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Cefuroxime, an antibiotic, can cause reversible encephalopathy in patients with kidney failure. This neurological syndrome, marked by confusion and tremors, may be overlooked in critically ill patients.

Area of Science:

  • Neurology
  • Pharmacology
  • Nephrology

Background:

  • Cefuroxime is a widely used cephalosporin antibiotic.
  • Encephalopathy is a general term for brain dysfunction.
  • Renal failure can impair drug clearance and increase toxicity risk.

Observation:

  • Four patients developed encephalopathy during cefuroxime therapy.
  • Symptoms included obtundation, stupor, myoclonic jerks, and asterixis.
  • Three of the affected patients had pre-existing renal failure.

Findings:

  • Cefuroxime therapy, particularly in overdose or in patients with renal impairment, can lead to a reversible encephalopathic syndrome.
  • The neurological symptoms observed are characteristic of toxic encephalopathy.
  • The syndrome may be underrecognized due to confounding factors in critically ill patients.

Related Experiment Videos

Implications:

  • Clinicians should consider cefuroxime as a potential cause of encephalopathy in patients with renal failure.
  • Early recognition and discontinuation of cefuroxime may lead to complete neurological recovery.
  • This highlights the importance of dose adjustment and monitoring in patients with impaired renal function.