Teaching a new dog old tricks?
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Updated: Oct 29, 2026

The Other End of the Leash: An Experimental Test to Analyze How Owners Interact with Their Pet Dogs
Published on: October 13, 2017
1Sir William Dunn School of Pathology, University of Oxford, UK. wigley@eric.path.ox.ac.uk
Abstract:
The recently determined crystal structures of fragments of the human and vaccinia virus type IB topoisomerases reveal unexpected similarity with the lambda family of site-specific recombinases. The conservation of structure suggests a common mechanism, indicating that topoisomerase activity may be the consequence of uncoupling DNA strand cleavage/religation from synapsis.
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