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Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
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The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel

T G Cachero1, A D Morielli, E G Peralta

  • 1Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Cell
|July 11, 1998
PubMed
Summary

The small GTP-binding protein RhoA interacts with and suppresses the activity of the Kv1.2 potassium channel. This RhoA-Kv1.2 interaction is crucial for receptor-mediated tyrosine kinase signaling pathways.

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