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[Perforating necrobiosis lipoidica: 2 cases]
I Lefaki1, G Vakali, O Mourelou
1Service de Dermatologie, Hôpital des maladies cutanées et venériennes, Thessaloniki, Grèce.
Annales De Dermatologie Et De Venereologie
|January 1, 1996
Summary
Perforating necrobiosis lipoidica, a rare diabetes complication, involves skin tissue elimination through perforations. This report details two cases, highlighting keratotic plugs and epidermal perforation, confirming a strong link to diabetes mellitus.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Perforating necrobiosis lipoidica is a rare variant of necrobiosis lipoidica.
- It is strongly associated with diabetes mellitus, particularly type II.
- Tissue elimination typically occurs through transfollicular perforations.
Observation:
- Two cases of perforating necrobiosis lipoidica associated with type II diabetes mellitus are presented.
- Key clinical features included keratotic plugs at the lesion periphery.
- One case showed predominantly transfollicular perforation, while the second exhibited epidermal perforation.
Findings:
- This study reports the first case of transepidermal elimination in perforating necrobiosis lipoidica.
- The findings reinforce the consistent association between this condition and diabetes mellitus.
- The presence of keratotic plugs is a significant clinical indicator.
Implications:
- This research expands the understanding of perforating necrobiosis lipoidica's clinical manifestations.
- It emphasizes the importance of recognizing this rare condition in diabetic patients.
- Further investigation into the mechanisms of transepidermal elimination in this context is warranted.