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[Acne induced by amineptin: adnexal toxiderma]
P Huet1, M Dandurand, J M Joujoux
1Service de Dermatologie, Hôpital Caremeau, CHRU Nîmes.
Annales De Dermatologie Et De Venereologie
|January 1, 1996
Summary
Amineptine-induced acne, a known side effect, can manifest unusually with direct toxicity to sweat glands. This case highlights adnexal toxic drug eruption, a rare reaction to amineptine.
Area of Science:
- Dermatology
- Toxicology
- Pharmacology
Background:
- Amineptine, an antidepressant, is known to cause acne with prolonged use.
- This case involves a young female drug addict with a history of benzodiazepine and alcohol abuse.
Observation:
- The patient presented with unusual inflammatory lesions.
- Histology revealed cystic dilatation of sebaceous glands and keratinizing syringometaplasia with neutrophilic eccrine hidradenitis in sudoriparous glands.
Findings:
- This is the second reported case of amineptine-induced adnexal toxicity.
- The findings suggest direct toxicity to sudoriparous glands, leading to accumulation of amineptine.
Implications:
- The term 'adnexal toxic drug eruption' is proposed for this reaction.
- This condition is similar to eruptions caused by chemotherapy, benaxoprofene, or other toxic agents.
- Highlights the importance of considering drug toxicity in unusual dermatological presentations.