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Determination of terbutaline based on oxidation by voltammetry
1Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
Journal of Pharmaceutical and Biomedical Analysis
|June 25, 1998
Summary
This study details a new voltammetric method for analyzing terbutaline using an activated glassy carbon electrode. The developed technique accurately quantifies terbutaline in pharmaceutical formulations.
Area of Science:
- Analytical Chemistry
- Electrochemistry
Background:
- Terbutaline is a bronchodilator used to treat asthma and other respiratory conditions.
- Accurate quantification of terbutaline in pharmaceutical formulations is crucial for quality control.
Purpose of the Study:
- To develop and validate a sensitive voltammetric method for the determination of terbutaline.
- To investigate the electrochemical oxidation of terbutaline at an activated glassy carbon electrode.
Main Methods:
- Voltammetric analysis using an activated glassy carbon electrode.
- Optimization of parameters including pH, scan rate, and buffer composition.
- Determination of terbutaline concentration in phosphate buffer (pH 6.0).
Main Results:
- Terbutaline undergoes irreversible oxidation at a high positive potential.
- A linear relationship was observed between peak current and terbutaline concentration (8 x 10(-6)-8 x 10(-4) M).
- The method demonstrated no interference from common pharmaceutical excipients.
Conclusions:
- The developed voltammetric method is selective and sensitive for terbutaline determination.
- This electrochemical approach is suitable for the quantitative analysis of terbutaline in tablet dosage forms.