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[ECG changes in dextran intolerance (author's transl)]

G Veltmann, R Mürtz

    Deutsche Medizinische Wochenschrift (1946)
    |October 8, 1976
    PubMed
    Summary
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    Dextran infusion can cause anaphylactoid reactions, leading to temporary ECG changes mimicking infarction. These cardiac events, associated with chest pain and low blood pressure, resolve rapidly.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Immunology

    Background:

    • Dextran is a plasma volume expander used clinically.
    • Anaphylactoid reactions can occur following dextran administration.
    • Cardiac manifestations of anaphylactoid reactions are not well-characterized.

    Observation:

    • A 46-year-old patient received 5-10 ml of dextran.
    • The patient developed ECG changes similar to myocardial infarction.
    • Symptoms included severe chest pain, tachycardia, and profound hypotension.

    Findings:

    • The patient experienced rapid recovery with ECG normalization within one hour.
    • No intermediate phase of cardiac dysfunction was observed.
    • These transient ECG changes are hypothesized to represent short-term coronary perfusion disturbance.

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    Implications:

    • This case suggests a potential link between dextran-induced anaphylactoid reactions and acute coronary events.
    • It highlights the importance of recognizing cardiac manifestations in anaphylactoid reactions.
    • Further research is warranted to understand the mechanism of dextran-induced coronary perfusion disturbances.