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Suppressor cells in rabbit peripheral blood

A L Luzzati, L Lafleur

    European Journal of Immunology
    |February 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Peripheral blood leukocytes (PBL) in rabbits contain suppressor cells that inhibit immune responses. Removing these cells enhances the secondary antibody response to sheep red cells (SRC) in vitro.

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    Area of Science:

    • Immunology
    • Cellular Immunology
    • Innate Immunity

    Background:

    • Autologous spleen cells primed to sheep red cells (SRC) exhibit a secondary in vitro response.
    • Peripheral blood leukocytes (PBL) can modulate this immune response.

    Purpose of the Study:

    • To identify and characterize the cells within rabbit PBL responsible for suppressing the secondary in vitro immune response to SRC.
    • To investigate the mechanism by which these suppressor cells inhibit lymphocyte proliferation and antibody production.

    Main Methods:

    • Fractionation of rabbit PBL using nylon wool adherence and velocity sedimentation.
    • In vitro culture of autologous spleen cells with SRC antigen.
    • Assessment of secondary antibody response and lymphocyte proliferation following PBL manipulation.

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    Main Results:

    • Removal of nylon wool adherent cells from PBL abolished the suppressive effect on the secondary anti-SRC response.
    • Velocity sedimentation separated suppressor cells from responding lymphocytes.
    • Lymphocytes freed from suppressor cell inhibition showed a reduced latency period and enhanced secondary in vitro anti-SRC response.

    Conclusions:

    • Rabbit PBL contain potent suppressor cells, distinct from granulocytes, platelets, or erythrocytes, that inhibit in vitro immune responses.
    • These suppressor cells can be isolated and their removal enhances adaptive immune recall responses.
    • Understanding these suppressor cells may offer insights into immune regulation and tolerance.