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Related Experiment Videos

Haematological changes in buprenorphine-treated mice

D Banerjee1, N K Sarkar

  • 1Postgraduate Department of Zoology, Presidency College, Calcutta, West Bengal, India.

Folia Biologica
|January 1, 1997
PubMed
Summary

Buprenorphine abuse in mice caused severe blood cell abnormalities, including low white blood cell counts and altered red blood cells. These changes in hematological parameters reversed after drug withdrawal.

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Area of Science:

  • Pharmacology
  • Hematology
  • Toxicology

Background:

  • Buprenorphine is a synthetic opioid analgesic.
  • It is abused as a heroin substitute by addicts.
  • Potential hematological effects of buprenorphine are not well-documented.

Purpose of the Study:

  • To investigate the effects of buprenorphine on hematological parameters in adult male Swiss mice.
  • To determine if chronic buprenorphine administration alters blood cell counts and hemoglobin levels.

Main Methods:

  • Adult male Swiss mice received daily intraperitoneal injections of buprenorphine (300 µg/kg) for 60 days.
  • Hematological parameters, including total and differential white blood cell counts, red blood cell counts, hematocrit, and hemoglobin, were analyzed.
  • Blood samples were examined for specific red blood cell and platelet abnormalities.

Main Results:

  • Chronic buprenorphine administration led to severe leucopenia (low white blood cell count).
  • Specific changes included decreased lymphocyte and monocyte counts, increased neutrophil count, and reduced hematocrit.
  • Observed abnormalities included red blood cell adherence to neutrophils and platelet satellitism.
  • Hematological parameters normalized within 45 days after drug withdrawal.

Conclusions:

  • Buprenorphine significantly impacts hematological parameters, causing notable blood cell abnormalities.
  • These adverse effects are reversible upon cessation of the drug.
  • Periodic monitoring of blood profiles is recommended for individuals abusing buprenorphine.

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