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Two new ergostane-type steroidal lactones from Withania coagulans
A Atta-ur-Rahman1, M I Choudhary, S Qureshi
1International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Journal of Natural Products
|June 27, 1998
Summary
Two novel steroidal lactones, coagulin F and coagulin G, were identified from the Withania coagulans plant. Their chemical structures were determined using comprehensive spectral analysis techniques.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Withania coagulans is a medicinal plant with a history of traditional use.
- Steroidal lactones, known as withanolides, are a class of bioactive compounds found in Withania species.
Purpose of the Study:
- To isolate and characterize new withanolides from Withania coagulans.
- To elucidate the chemical structures of these novel compounds.
Main Methods:
- Phytochemical investigation of Withania coagulans whole plant extract.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through extensive spectroscopic analysis (e.g., NMR, MS).
Main Results:
- Two new withanolides, designated coagulin F and coagulin G, were successfully isolated.
- The complete chemical structures of coagulin F and coagulin G were determined.
- Coagulin F: 27-hydroxy-14,20-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide.
- Coagulin G: 17beta,27-dihydroxy-14,20-epoxy-1-oxo-(22R)-witha-2,5, 24-trienolide.
Conclusions:
- The study expands the known chemical diversity of withanolides from Withania coagulans.
- The identified compounds, coagulin F and coagulin G, represent novel additions to the withanolide family.
- Further research may explore the biological activities of these new compounds.