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Cytokines in hematopoiesis

W S Alexander1

  • 1Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Victoria, Australia.

International Reviews of Immunology
|July 1, 1998
PubMed
Summary

Hematopoiesis, the creation of blood cells, is regulated by cytokines like colony-stimulating factors and erythropoietin. Genetic studies in mice reveal the crucial roles of these regulators and their receptors in blood cell production.

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Area of Science:

  • Hematology
  • Molecular Biology
  • Immunology

Background:

  • Hematopoiesis is the complex process of blood cell formation from stem cells.
  • This process is regulated by cellular interactions and soluble cytokines.
  • Over twenty cytokines influencing hematopoietic cells are known and available recombinantly.

Purpose of the Study:

  • To summarize the regulatory mechanisms of hematopoiesis.
  • To highlight the roles of key cytokines in blood cell production.
  • To discuss insights gained from genetically engineered mouse models.

Main Methods:

  • Review of existing literature on hematopoiesis and cytokine regulation.
  • Analysis of studies involving genetically engineered mice lacking specific cytokine regulators or receptors.
  • In vitro and in vivo experimental data on cytokine activities.

Main Results:

  • Colony-stimulating factors, erythropoietin, and thrombopoietin are key regulators of specific blood cell lineages.
  • Genetic studies in mice lacking these regulators or their receptors have elucidated their physiological importance.
  • Cytokine activities have been extensively characterized through in vitro and in vivo experiments.

Conclusions:

  • Cytokines play essential roles in regulating hematopoiesis.
  • Genetically engineered mouse models provide critical insights into cytokine function.
  • These cytokines have been developed into valuable clinical reagents.

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