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Nutritional modulation of immunity and the inflammatory response
1Department of Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
Nutrition (Burbank, Los Angeles County, Calif.)
|July 1, 1998
Summary
Nutritional therapy for injured patients aims to restore metabolism and immune function. Evidence is reviewed to determine its effectiveness in managing metabolic stress and inflammation.
Area of Science:
- Metabolic response to injury and stress
- Immunonutrition
- Clinical nutrition
Background:
- Metabolic derangements in injured patients are influenced by insult severity, comorbidities, and energy reserves.
- The inflammatory response to injury involves mediators affecting cellular and organ function.
- Prolonged nutritional deprivation can lead to immunocompromise, organ injury, and mortality.
Purpose of the Study:
- To assess the efficacy of nutritional therapeutics in injured patients.
- To evaluate the role of nutrition in modulating the immune response to injury and stress.
- To review biological and clinical evidence supporting nutritional interventions.
Main Methods:
- Review of available biological and clinical evidence.
- Analysis of factors governing metabolic response to injury.
- Examination of the impact of nutritional therapy on immune function.
Main Results:
- Nutritional therapy is proposed to restore metabolism, wound healing, and immune competence.
- Debate exists regarding the current efficacy of nutritional therapy in modulating immune responses.
- The effectiveness of nutritional interventions depends on various patient and injury-related factors.
Conclusions:
- Optimal nutrient supply is crucial for managing metabolic stress and supporting recovery.
- Further research is needed to clarify the precise benefits of nutritional therapy in modulating inflammation.
- Evidence suggests a potential role for nutritional therapeutics in improving outcomes for injured patients.