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Syndromes of thrombosis and hypercoagulability. Congenital and acquired causes of thrombosis

R L Bick1, H Kaplan

  • 1Department of Medicine (Hematology/Oncology), University of Texas Southwestern Medical Center, Dallas 75231, USA.

The Medical Clinics of North America
|July 1, 1998
PubMed

Insights

Blood protein and platelet defects cause most unexplained thrombosis. Identifying these defects guides treatment and prevents future clotting events in patients and families.

Area of Science:

  • Hematology
  • Vascular Medicine
  • Genetics

Background:

  • Unexplained venous thrombosis and arterial thrombotic/ischemic events are common.
  • Blood coagulation protein and platelet defects are significant underlying causes.

Purpose of the Study:

  • To summarize common and uncommon blood protein and platelet defects.
  • To guide the suspicion and investigation of these defects in patients with thrombotic events.

Main Methods:

  • Review of scientific literature on blood coagulation and platelet disorders.
  • Analysis of the etiological contribution of these defects to thrombotic events.

Main Results:

  • Blood coagulation protein and platelet defects account for up to 90% of unexplained venous thrombosis.
  • These defects are responsible for up to 70% of unexplained arterial thrombotic or ischemic events.

Conclusions:

  • Defining specific defects is crucial for effective secondary prevention strategies.
  • Identification impacts antithrombotic therapy duration and primary prevention in families with hereditary defects.

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