Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement system is not activated in primary biliary cirrhosis

M Gardinali1, L Conciato, C Cafaro

  • 1Institute of Internal Medicine, IRCCS Ospedale Policlinico, Milan, Italy.

Clinical Immunology and Immunopathology
|July 1, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flow cytometry and capillary electrophoresis analyses in ethanol-stressed Oenococcus oeni strains and changes assessment of membrane fatty acid composition.

Journal of applied microbiology·2017
Same author

Geostatistical simulations for radon indoor with a nested model including the housing factor.

Journal of environmental radioactivity·2015
Same author

Definition of radon prone areas in Friuli Venezia Giulia region, Italy, using geostatistical tools.

Journal of environmental radioactivity·2014
Same author

Adaptive changes in geranylgeranyl pyrophosphate synthase gene expression level under ethanol stress conditions in Oenococcus oeni.

Journal of applied microbiology·2013
Same author

Systemic sclerosis and cancer.

International journal of immunopathology and pharmacology·2009
Same author

Acute liver and renal failure during treatment with buprenorphine at therapeutic dose.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2008
Same journal

Mechanisms of virus replication, persistence, and regulation of immune responses.

Clinical immunology and immunopathology·2020
Same journal

Cumulative subject index for volumes 86-89

Clinical immunology and immunopathology·1998
Same journal

D-penicillamine-induced pancreatic islet autoantibody production is independent of the immunogenetic background: a lesson from patients with Wilson's disease.

Clinical immunology and immunopathology·1998
Same journal

Characterization of gastric Na+/I- symporter of the rat.

Clinical immunology and immunopathology·1998
Same journal

CD8(+), radiosensitive T cells of parental origin, oppose cells capable of down-regulating cytotoxicity in murine acute lethal graft-versus-host disease.

Clinical immunology and immunopathology·1998
Same journal

Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus.

Clinical immunology and immunopathology·1998
See all related articles

Complement system activation is not implicated in primary biliary cirrhosis (PBC). Elevated C3 levels in PBC patients are linked to cholestasis, not liver inflammation or complement activation.

Area of Science:

  • Immunology
  • Hepatology
  • Complement System Biology

Background:

  • Controversial evidence suggests chronic complement system activation in primary biliary cirrhosis (PBC), potentially contributing to bile duct injury.
  • Previous studies lacked sensitive methods to accurately assess complement activation in PBC.

Purpose of the Study:

  • To reevaluate complement system activation in primary biliary cirrhosis (PBC) using sensitive assays.
  • To investigate the relationship between complement activation by-products and disease progression in PBC.

Main Methods:

  • Measured plasma by-products of complement activation (C4a, C3a, Bb, SC5b-9) in 44 PBC patients.
  • Included age-matched healthy women and patients with chronic hepatitis as controls.
  • Utilized sensitive methods to detect complement activation, including C3a/C3 ratio and C-reactive protein levels.

Related Experiment Videos

Main Results:

  • PBC patients showed normal C4a and Bb levels, refuting classical and alternative pathway activation.
  • Minor C3a increases were observed in some PBC patients, but the C3a/C3 ratio remained similar across groups.
  • Elevated C3 concentrations were found in early-stage PBC and chronic cholestatic syndromes, correlating with bilirubin levels and cholestasis, not inflammation.

Conclusions:

  • The complement system is not chronically activated in primary biliary cirrhosis (PBC).
  • Increased serum C3 levels in PBC are associated with cholestasis, independent of liver inflammation or complement activation.
  • Findings suggest cholestasis, not complement activation, is linked to altered C3 levels in PBC.