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Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
Published on: November 15, 2019
The transition to extrauterine life and disorders of transition
1Department of Pediatrics, University of Utah Medical Center, Salt Lake City, USA.
Insights
Newborns may be discharged before completing the transition to life outside the womb. This review covers neonatal transition physiology and common disorders, aiding early detection and risk assessment for infant health.
Area of Science:
- Neonatology
- Physiology
- Pediatrics
Background:
- Shorter postnatal hospital stays increase the risk of early infant discharge.
- Infants undergo significant physiological changes during the neonatal transition period.
- Early identification of neonatal problems during this transition is crucial.
Purpose of the Study:
- To review the physiology of neonatal transition.
- To discuss common disorders occurring during this critical period.
- To identify factors associated with higher risk for neonatal transitional problems.
Main Methods:
- Literature review of neonatal transition physiology.
- Analysis of common neonatal transitional disorders.
- Identification of risk factors for neonatal complications.
Main Results:
- Most neonatal transition disorders manifest within expected postnatal timeframes.
- Understanding transition physiology aids in anticipating and treating neonatal issues.
- Specific clinical factors help identify infants at elevated risk.
Conclusions:
- Early discharge necessitates awareness of neonatal transition challenges.
- Timely recognition and management of transitional disorders are essential for infant well-being.
- Clinicians can utilize identified risk factors for proactive infant care.
Abstract:
With shorter postnatal hospital stays, concern has arisen that many infants may be discharged prior to completion of the transition to extrauterine life, a time of dynamic physiologic change when many neonatal problems may present. This article reviews the physiology of the neonatal transition together with common transitional disorders. Most disorders of transition present at typical postnatal time periods, permitting their timely anticipation and treatment. Moreover, many are associated with factors that may further aid the clinician in defining those infants at highest risk.
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