Permeability of chorion laeve to succinylcholine in vitro

The simultaneous diffusion of 14C-succinylcholine and p-amino hippurate across human placental tissue in vitro was measured. Column chromatographic purification of the radioactivity followed by paper chromatographic analysis showed little alteration of the succinylcholine during the course of these experiments. Similar chloroform-buffer partition coefficients for the two solutes were measured. Thus in these experiments, the nearly identical transfer rates of these two similar sized, lipid-insoluble compounds indicated that succinylcholine crosses human placental tissue in quantitites compatible with its molecular size and lipophobic nature, and that the diffusion rate is not significantly influenced by its increased molecular charge.